多能干细胞成功诱导为胰岛细胞

2014/10/27 10:45:57 本站原创 佚名 【字体:

哈佛大学的研究人员摸索出一种新方法,成功将大量人多能干细胞诱导为胰岛细胞。

Stem Cells Can Be Turned Into Functional Human Pancreatic β Cells

Pagliuca FW et al., Cell 2014 Oct 9; 159:428

A new culture method can produce billions of functional, differentiated cells.


The discoveries of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have sparked hope that new cells can be created to replace cells destroyed by disease. However, ESCs and iPSCs must be coaxed to become specific differentiated cells, and the factors for doing so are not well understood.

A team from the Harvard Stem Cell Institute reports that it has discovered a combination of factors that, when placed in the culture media around human stem cells, transforms them into functioning pancreatic β cells in a few weeks. These β cells promptly started to produce insulin in response to repeated glucose challenges both in vitro and when they were placed into diabetic mice. The cells restored normoglycemia in a controlled fashion (without causing hypoglycemia). Experience with human islet transplantation indicates that the number of β cells produced by this method is sufficient to treat diabetes in humans successfully.

Until this report, experiments with stem cells had not produced mature, functional β cells in sufficient numbers to cure patients with type 1 diabetes. These findings are being hailed as a landmark in stem cell biology, because they suggest that cell-availability limitations have been overcome for treating type 1 diabetes.
 
Citation(s):
 
Pagliuca FW et al. Generation of functional human pancreatic β cells in vitro. Cell 2014 Oct 9; 159:428. (http://dx.doi.org/10.1016/j.cell.2014.09.040)

相关阅读: