新注射技术可促进脊髓损伤修复能力

2020/7/27 16:28:37 本站原创 佚名 【字体:

 

 

 

New injection technique may boost spinal cord injury repair efforts

新注射技术可促进脊髓损伤修复能力

 

编译    廖联明

 

Writing in the journal Stem Cells Translational Medicine, an international research team, led by physician-scientists at University of California San Diego School of Medicine, describe a new method for delivering neural precursor cells (NSCs) to spinal cord injuries in rats, reducing the risk of further injury and boosting the propagation of potentially reparative cells.

由加州大学圣地亚哥医学院的临床科学家领导的国际研究团队在《干细胞转化医学》杂志上发表文章,讲述了一种将神经前体细胞(NSCs)递送到大鼠损伤脊髓中的新方法,减少进一步损伤的风险,并促进潜在修复细胞的增殖。

 

NSCs hold great potential for treating a variety of neurodegenerative diseases and injuries to the spinal cord. The stem cells possess the ability to differentiate into multiple types of neural cell, depending upon their environment. As a result, there is great interest and much effort to use these cells to repair spinal cord injuries and effectively restore related functions.

神经干细胞在治疗各种神经退行性疾病和脊髓损伤方面具有巨大的潜力。干细胞具有根据其所处的环境分化成多种类型的神经细胞的能力。因此,利用这些细胞修复脊髓损伤并有效地恢复相应功能是非常有意义并值得研究的。

 

But current spinal cell delivery techniques involve direct needle injection into the spinal parenchyma -- the primary cord of nerve fibers running through the vertebral column. As such, there is an inherent risk of (further) spinal tissue injury or intraparechymal bleeding.

但是目前的脊髓细胞递送技术涉及直接针注射到脊髓实质中。脊髓实质是穿过脊柱的主要神经纤维索。 因此,存在导致(进一步)脊柱组织损伤或动脉内膜内出血的内在风险。

 

The new technique is less invasive, depositing injected cells into the spinal subpial space -- a space between the pial membrane and the superficial layers of the spinal cord.

这项新技术具有较小创伤性,它可以将细胞递送到脊髓软膜和脊髓表层之间的椎管膜下间隙中。

 

This injection technique allows the delivery of high cell numbers from a single injection. Cells with proliferative properties, such as glial progenitors, then migrate into the spinal parenchyma and populate over time in multiple spinal segments as well as the brain stem. Injected cells acquire the functional properties consistent with surrounding host cells.

这种注射技术可一次注射大量细胞。 具有增殖特性的细胞(例如神经胶质祖细胞)然后迁移到脊髓实质中,并随着时间的推移进入多个脊髓节段以及脑干中。 注射的细胞获得与周围宿主细胞一致的功能特性。

 

subpially-injected cells are likely to accelerate and improve treatment potency in cell-replacement therapies for several spinal neurodegenerative disorders in which a broad repopulation by glial cells, such as oligodendrocytes or astrocytes, is desired.This may include spinal traumatic injury, amyotrophic lateral sclerosis and multiple sclerosis.

软膜下注射的细胞可能会加速和改善针对几种脊柱神经退行性疾病的细胞替代疗法的治疗效果,这些疗法中须要大量的胶质细胞,如少突胶质细胞或星形胶质细胞。这些疾病包括脊髓创伤、肌萎缩侧索硬化症和多发性硬化症。

 

The researchers plan to test the cell delivery system in larger preclinical animal models of spinal traumatic injury that more closely mimic human anatomy and size. The goal is to define the optimal cell dosing and timing of cell delivery after spinal injury, which is associated with the best treatment effect

研究人员计划在更大的脊髓损伤临床前动物模型中测试细胞递送系统,这些模型须要更接近人体解剖结构和大小。 目标是确定脊髓损伤后细胞的最佳给药量和给药时机,从而获得最佳治疗效果。

 

 

   Journal Reference:   

Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. STEM CELLS Translational Medicine, 2019; 9 (2): 177 DOI: 10.1002/sctm.19-0156

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